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Laleh Golshahi, Ph.D.

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Laleh Golshahi, Ph.D.Laleh VCU Photo

Assistant Professor, Department of Mechanical and Nuclear Engineering
Phone: (804) 827-3742
Fax: (804) 827-7030
Email: lgolshahi@vcu.edu
Website: http://wp.vcu.edu/lgolshahi/

Address
Virginia Commonwealth University
School of Engineering
Department of Mechanical and Nuclear Engineering
Biotech One, Suite 1083
800 E. Leigh St.
Richmond, VA, 23219

Education

  • Post-Doctoral Fellow in Pharmaceutics, Virginia Commonwealth University, 2014
  • Ph.D. in Mechanical Engineering, University of Alberta, 2012
  • M.S. in Mechanical Engineering, University of Calgary, 2007
  • B.S. in Mechanical Engineering, Tehran Polytechnique, 2002

Awards and Honors

  • Dissertation Fellowship, University of Alberta, Canada (2011-2012)
  • President’s Doctoral Prize of Distinction, University of Alberta, Canada (2009-2011)
  • Natural Sciences and Engineering Research Council (NSERC), PGS National Doctoral Award, Canada (2009-2011)
  • Alberta Innovates Provincial Graduate Scholarship, Canada (2008-2011)
  • Saddler Doctoral Award, University of Alberta, Canada (2008)
  • Provost Doctoral Recruitment Scholarship, University of Alberta, Canada (2007-2009)
  • Best Graduate Podium Presentation Award, University of Calgary, Canada (2007)

Research topics

  • Two-Phase (Gas-Solid) Flow
  • Applications: Occupational Health Protection; Ambient/Indoor Air Quality Control; Gas Filtration
  • Respiratory Fluid Mechanics and Transport Phenomena
  • Applications: Imaging, Modeling, and Physiology of Aerosols and Medical Gases in the Lungs
  • Aerosol Science and Medicine
  • Applications: Design and Development of Medical Respiratory Devices with Emphasis on Pediatric Respiratory Drug Delivery
  • Health related aerosol exposure control
  • Gas and aerosol transport in biological systems
  • Gas-solid separation and filtration
  • Heating, ventilation and air conditioning
  • Biotherapeutics
  • Applications: Eradication of Antibiotic Resistant Microorganisms
  • Particle Engineering
  • Applications: Modifications of Spray Drying Techniques; Targeted Drug Delivery

 

Publications

Book Chapters

Golshahi, L. and Finlay, W. H., “Recent advances in understanding gas and aerosol transport in the lungs: application to predictions of regional deposition”, Advances in transport phenomena 2009, DOI: 10.1007/978-3-642-02690-4_1, edited by: Liqiu Wang, Springer Berlin-Heidelberg, pp 1-30, 2009.

Patents

• Finlay, W. H. and Golshahi, L. (2012) Idealized child oral airway replica for aerosol testing. Licensed by Copley Scientific, UK.

Journal Papers

• Golshahi, L., Longest, P. W., Azimi, M., and Hindle, M. (2014) Intermittent aerosol delivery to the lungs during high flow nasal cannula therapy. Respiratory Care. Accepted on February 10, 2014.

• Ruzycki, C., Golshahi, L., Vehring, R., and Finlay, W. H. (2014) Comparison of in vitro deposition of pharmaceutical aerosol in an idealized child throat with in vivo deposition in the upper respiratory tract of children. Pharmaceutical Research. DOI: 10.1007/s11095-013-1258-2.

• Amirav, I., Halamish, A., Newhouse, M. T., and Golshahi, L. (2014) Nasal versus oral aerosol delivery to the “lungs” in infants and toddlers. Pediatric Pulmonology. DOI:10.1002/ppul.22999.

• Longest, P. W., Azimi, M., Golshahi, L., and Hindle, M. (2013) Improving aerosol delivery during invasive mechanical ventilation with redesigned components. Respiratory Care. DOI:10.4187/respcare.02782.

• Carrigy, N., Ruzycki, C., Golshahi, L., and Finlay, W. H. (2013) Pediatric in vitro and in silico models of deposition via oral and nasal inhalation. Journal of Aerosol Medicine and Pulmonary Drug Delivery. Accepted on August 20, 2013. In press.

• Golshahi, L., Tian, G., Azimi, M., Son, Y. J., Walenga, R., Longest, P. W., and Hindle, M. (2013) The use of condensational growth methods for efficient drug delivery to the lungs during noninvasive ventilation high flow therapy. Pharmaceutical Research. 30(11): 2917-2930.

• Longest, P. W., Golshahi, L., and Hindle, M. (2013) Improving pharmaceutical aerosol delivery during noninvasive ventilation: effects of streamlined components. Annals of Biomedical Engineering. 41(6): 1217-1232.

• Golshahi, L., Noga, M. L., Vehring, R., and Finlay, W. H. (2013) An In vitro study on the deposition of micrometer-sized particles in the extrathoracic airways of adults during tidal oral breathing. Annals of Biomedical Engineering. 41(5): 979-989.

• Golshahi, L., Vehring, R., Noga, M. L. and Finlay, W. H. (2013) In vitro deposition of micrometer-sized particles in the extrathoracic airways of children during tidal oral breathing. Journal of Aerosol Science. 57: 14-21.

• Javaheri, E., Golshahi, L. and Finlay, W. H. (2013) An idealized geometry that mimics average infant nasal airway deposition. Journal of Aerosol Science. 55: 137-148.

• Golshahi, L., Telidetzki, K., King, B., Shaw, D., and Finlay, W. H. (2013) A pilot study on the use of geometrically accurate face replicas to replicate ex vivo N95 mask fit. American Journal of Infection Control. 41(1): 77-79.

• Golshahi, L. and Finlay, W. H. (2012) An idealized child throat that mimics average pediatric oropharyngeal deposition. Aerosol Research Letter, Aerosol Science and Technology. 46 (5):i-iv.

• Golshahi, L., Noga, M. L., and Finlay, W. H. (2012) Deposition of inhaled micrometer-sized particles in oropharyngeal airway replicas of children at constant flow rates. Journal of Aerosol Science. 49: 21-31.

• Golshahi, L., Noga, M. L., Thompson, R. B., and Finlay, W. H. (2011) In vitro deposition measurement of inhaled micrometer-sized particles in extrathoracic airways of children and adolescents during nose breathing. Journal of Aerosol Science. 42 (7): 474-488.

• Golshahi, L., Lynch, K. H., Dennis, J. J., and Finlay, W. H. (2011) In vitro lung delivery of bacteriophages KS4-M and PhiKZ using dry powder inhalers for treatment of Burkholderia cepacia complex and Pseudomonas aeruginosa infections in cystic fibrosis. Journal of Applied Microbiology. 110 (1): 106-117.

• Golshahi, L., Finlay, W. H., Olfert, J. S., Thompson, R. B., and Noga, M. L. (2010) Deposition of inhaled ultrafine aerosols in replicas of nasal airways of infants. Aerosol Science and Technology. 44: 741-752.

• Golshahi, L., Tan, Z. C., and Abedi, J. (2009) Granular filtration for airborne particles: correlation between experiments and models. Canadian Journal of Chemical Engineering.87(5): 726-731.

• Golshahi, L., Seed, K. D., Dennis, J.J., and Finlay, W. H. (2008) Toward modern inhalational bacteriophage therapy: nebulization of bacteriophages of Burkholderia Cepaci Complex. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 21(4): 351-359.

• Golshahi, L., Tan, Z. C., and Abedi, J. (2008) Granular filtration for airborne nanoparticles. ASHRAE Transactions. 114 (2): 533-540.

Conference Papers

• Golshahi, L., Longest, P. W., Behara, S. R. B., Farkas, D. R., and Hindle M. (2014) Active dry powder inhaler system for nose-to-lung delivery of an excipient enhanced growth formulation, Proceedings of Respiratory Drug Delivery 2014, Fajardo, PR, USA, May 4-8.

• Finlay, W. H., Ruzycki, C., Golshahi, L., Vehring, R. (2014) Validating and scaling the Alberta Idealized Child Throat, Proceedings of Respiratory Drug Delivery 2014, Fajardo, PR,USA, May 4-8.

• Finlay, W. H., Golshahi, L., Noga, M. L. (2012) New validated extrathoracic and pulmonary deposition models for infants and children, Proceedings of Respiratory Drug Delivery 2012, Phoenix, AZ, USA, May 13-17, Vol 1, p. 325-336.

• Finlay, W. H., Golshahi, L., Noga, M. L. and Flores-Mir, C. (2010) Choosing 3-D mouth- throat dimensions: a rational merging of medical imaging and aerodynamics, Proceedings of Respiratory Drug Delivery 2010, Orlando, FL, USA, April 25-29, Vol 1, p. 185-194.

Conference Abstracts and Presentations

• Golshahi, L., Longest, P. W., Azimi, M., Walenga, R., and Hindle, M. (2013) In vitro aerosol delivery to the lungs during non-invasive ventilation high flow therapy American Association for Aerosol Research (AAAR) 32nd Annual Conference, Portland, OR, USA, Sep 30-Oct 4.

• Golshahi, L., Azimi, M., Hindle, M., and Longest, P. W. (2013) Streamlined designs to reduce aerosol deposition losses in circuits used for invasive and non-invasive ventilation, 19th Congress of International Society for Aerosols in Medicine (ISAM), Chapel Hill, NC, USA, entree for best oral presentation and poster presentation, April 6-10.

• Finlay, W. H., Golshahi, L., Javaheri, E. and Ruzycki, C. (2012) Idealized infant and child throats for mimicking average extrathoracic deposition, American Association for Aerosol Research (AAAR) 31st Annual Conference, Minneapolis, MN, USA, oral presentation, Oct 8-12.

• Golshahi, L., Noga, M. L., and Finlay, W. H. (2011) Experimentally-measured aerosol deposition in replicas of oropharyngeal airways of children during moderate to high constant flow rates, American Association for Aerosol Research (AAAR) 30th Annual Conference, Orlando, FL, USA, oral presentation, Oct 3-7.

• Finlay, W. H., Golshahi, L., Lynch, K. H., Matinkhoo, S., Dennis, J. J., and Vehring, R. (2011) Respirable powders containing bacteriophages active against Burkholderia cepacia complex and Pseudomonas aeruginosa gram-negative bacteria, Particulate Processes in the Pharmaceutical Industry III, Gold coast, Australia, oral presentation , July 24-29.

• Golshahi, L., Noga, M. L., Thompson, R. B., and Finlay, W. H. (2011) Measuring deposition of inhaled micrometer-sized particles in nasal airways of children and adolescents in vitro, 18th Congress of International Society for Aerosols in Medicine (ISAM), Rotterdam, Netherland, poster presentation, June 18-22.

• Matinkhoo, S., Golshahi, L., Lynch, K. H., Dennis, J. J., Finlay, W. H., and Vehring, R. (2011) Developing dry powders containing bacteriophages for the treatment of bacterial lung infections, 18th Congress of International Society for Aerosols in Medicine (ISAM), Rotterdam, Netherland, poster presentation, June 18-22.

• Golshahi, L., Noga, M. L., Thompson, R. B., and Finlay, W. H.* (2011) In vitro deposition measurement of inhaled micrometer-sized particles in nasal airways of school age children and adolescents, Advanced Digital Technologies in Head and Neck Reconstruction (ADT), Freiburg, Germany, poster presentation, May 5-8.

• Golshahi, L., Zuberbuhler, P., and Finlay, W. H. (2010) In vitro comparison of lung delivery of Xopenex and Flovent HFA using Vortex and AeroChamber Plus holding chambers, CHEST Annual Conference, Vancouver, BC, Canada, poster presentation, Oct 30- Nov 4.

• Golshahi, L., Lynch, K. H., Dennis, J. J., and Finlay, W. H. (2010) In vitro lung delivery of respirable powders containing bacteriophages PhiKZ and KS4-M for treatment of Burkholderia Cepacia Complex and Pseudomonas Aeruginosa infections in cystic fibrosis, American Association for Aerosol Research (AAAR) 29th Annual Conference, Portland, OR, USA, oral presentation, Oct 25-29.

• Golshahi, L., Finlay, W. H., Olfert, J. S., Thompson, R. B. and Noga, M. L. (2010) In vitro deposition measurement of inhaled ultrafine aerosols in nasal airways of infants, International Aerosol Conference (IAC), Helsinki, Finland, poster presentation, Aug 29- Sep 3.

• Golshahi, L., Finlay, W. H., Olfert, J. S., Thompson, R. B. and Noga, M. L. (2010) Deposition of Inhaled Ultrafine Aerosols in Replicas of Nasal Airways of Infants, Graduate Research Symposium, University of Alberta, poster presentation, June 17.

• Golshahi, L., W. H. Finlay, M. Noga , J. Olfert, and R. Thompson (2009) Deposition of Inhaled Ultrafine Aerosols in Replicas of Nasal Airways of Infants, American Association for Aerosol Research (AAAR) 28th Annual Conference, Minneapolis, MN, USA, oral presentation, Oct 26-30.

• Golshahi, L., Tan, Z.C., and Abedi, J. (2008) Granular filtration for airborne nanoparticles, American Society of Heating, Refrigeration, and Air-Conditioning Engineers (ASHRAE) Annual Meeting, Salt Lake City, UT, USA, poster presentation, June 21-25. Conference Papers

• Golshahi, L., Tan, Z. C., and Abedi, J. (2007) Experimental and modeling studies of granular filtration for airborne particles, 57th Canadian Chemical Engineering Conference, Edmonton, AB, Canada, oral presentation, October 28-31.

• Golshahi, L., Tan, Z. C., and Abedi, J. (2006) Design and performance evaluation of a novel uniflow cyclone, Engineering Conferences International: Control of Particulate Processes VII, Harrison Hot Springs, BC, Canada, oral presentation, Oct 29- Nov 2.